## Abstract Distant metastasis is the major cause of death in colorectal cancer (CRC) patients. To identify genes influencing the prognosis of patients with CRC, we compared gene expression in primary tumors with and without distant metastasis using an oligonucleotide microarray. We also examined t
Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer
β Scribed by Salazar, R.; Roepman, P.; Capella, G.; Moreno, V.; Simon, I.; Dreezen, C.; Lopez-Doriga, A.; Santos, C.; Marijnen, C.; Westerga, J.; Bruin, S.; Kerr, D.; Kuppen, P.; van de Velde, C.; Morreau, H.; Van Velthuysen, L.; Glas, A. M.; Van't Veer, L. J.; Tollenaar, R.
- Book ID
- 125516265
- Publisher
- American Society of Clinical Oncology
- Year
- 2011
- Tongue
- English
- Weight
- 177 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0732-183X
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## Abstract UICC stage II and III colorectal cancers (CRC) differ fundamentally in prognosis and therapeutic concepts. To analyze differential gene expression between both stages and to establish a relationship between molecular background and clinical presentation, tumor material from 36 unselecte
Background: The expression of matrix metalloproteinase-21 (MMP-21) has been shown to be elevated in some solid tumor and thought to enhance tumor invasion and metastasis ability. In the present study, we investigated the expression of MMP-21 and its association with prognosis in stage II and III col