Gene Expression Profiling Reveals Unique Molecular Subtypes of Neurofibromatosis Type I-associated and Sporadic Malignant Peripheral Nerve Sheath Tumors
โ Scribed by Mark A. Watson; Arie Perry; Tarik Tihan; Richard A. Prayson; Abhijit Guha; Julia Bridge; Rosalie Ferner; David H. Gutmann
- Book ID
- 111404273
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 684 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1015-6305
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Cytogenetic studies in small groups of patients with malignant peripheral-nerve-sheath tumors (MPNST) revealed complex karyotypes with no consistent changes. A computerassisted cytogenetic analysis using a cytogenetic database was performed to determine recurrent cytogenetic alterations in 51 MPNSTs
Neurofibromatosis type-1 (NF1) is associated with the growth of benign and malignant tumors. Approximately 15% of NF1 patients develop malignant peripheral nerve sheath tumors (MPNSTs), underlining the need to identify specific diagnostic/prognostic biomarkers associated with MPNST development. The