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Gene expression profiling of primary and metastatic colorectal cancer

✍ Scribed by C. Belluco; A. D'Arrigo; M. Digito; G. Esposito; A. Ambrost; A. Bertola; E. Mammano; A. Leon; D. Nitti; M. Lise

Book ID: 110547811
Publisher: Springer
Year: 2004
Tongue: English
Weight: 154 KB
Volume: 11
Category: Article
ISSN: 1068-9265
DOI: 10.1007/bf02524153

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␤-catenin plays a fundamental role in the regulation of the E-cadherin-catenin cell adhesion complex. It also functions in growth signalling events, independently of the cadherincatenin complex, and these signalling pathways are disturbed in colorectal cancer. Mutations in either the APC or ␤-cateni