Gene-Expression Profiling of Experimental Autoimmune Encephalomyelitis
β Scribed by Eilhard Mix; Jens Pahnke; Saleh M. Ibrahim
- Book ID
- 110401897
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 550 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0364-3190
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We previously reported that recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) is associated with the appearance of suppressor T cells (Ts). These Ts secrete TGF-beta which down-regulates the production of inflammatory cytokines by the effector T cells that mediate this dise
## Abstract Transgenic mice with Tβcell receptor (TCR) specific for myelin basic protein (MBP)βAc1β11 peptide and homozygous for the RAGβ1 mutation (T/Rβ mice) spontaneously develop acute progressive experimental autoimmune encephalomyelitis (SpβEAE) mediated by CD4+ T cells. Microarray analysis of