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Gene expression profiling of ErbB receptor and ligand-dependent transcription

✍ Scribed by Amin, Dhara N; Perkins, Archibald S; Stern, David F


Book ID
110068338
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
232 KB
Volume
23
Category
Article
ISSN
0950-9232

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The mechanism by which ErbB2 exerts its oncogenic effect is poorly defined. In this article we show that ErbB2 co-expression slows ligand-dependent growth factor receptor downregulation in NIH 3T3 transfectants. Ligand dependence of cell growth and MAP kinase signaling are retained in epidermal grow