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Gene expression profiling of advanced lung cancer

✍ Scribed by Simone Petersen; Cordula Heckert; Jacqueline Rudolf; Karsten Schlüns; Oleg I. Tchernitsa; Reinhold Schäfer; Manfred Dietel; Iver Petersen

Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
132 KB
Volume
86
Category
Article
ISSN
0020-7136

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✦ Synopsis

Lung cancer is a highly aggressive neoplasm with 85% mortality. To identify new tumor-associated genes, we compared the expression profile of a primary metastasizing adenocarcinoma with normal airway epithelial cells. Two cDNA libraries of up-and downregulated genes were generated, comprising 253 and 299 clones, respectively. The sequence analysis revealed 205 different known genes and 314 cDNA fragments of unknown functions. Northern-blot analysis of 167 clones confirmed differential expression in 58%, and indicated a similar expression pattern in additional lung-cancer cell lines for selected clones, strengthening the value of this model for the identification of new candidate genes in lung carcinogenesis. Int.

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