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Gene expression profiling as functional readout of rodent models for psychiatric disorders

✍ Scribed by Raffaella Molteni, Flavia Macchi, Marco A. Riva


Book ID
120909517
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
197 KB
Volume
354
Category
Article
ISSN
0302-766X

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## Abstract Sly disease (MPS VII) is an autosomal‐recessive lysosomal storage disorder resulting from beta‐glucuronidase deficiency, which is characterized by a severe neurological impairment. MPS VII mice accumulate undegraded glycosaminoglycans and mimic the human neurodegenerative disorder, thus