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Gene expression profiles in liver of mouse after chronic exposure to drinking water

✍ Scribed by Bing Wu; Yan Zhang; Dayong Zhao; Xuxiang Zhang; Zhiming Kong; Shupei Cheng

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 273 KB
Volume: 29
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.1441

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

cDNA micorarray approach was applied to hepatic transcriptional profile analysis in male mouse (Mus musculus, ICR) to assess the potential health effects of drinking water in Nanjing, China. Mice were treated with continuous exposure to drinking water for 90 days. Hepatic gene expression was analyzed with Affymetrix Mouse Genome 430A 2.0 arrays, and pathway analysis was carried out by Molecule Annotation System 2.0 and KEGG pathway database. A total of 836 genes were found to be significantly altered (1.5‐fold, P ≤ 0.05), including 294 up‐regulated genes and 542 down‐regulated genes. According to biological pathway analysis, drinking water exposure resulted in aberration of gene expression and biological pathways linked to xenobiotic metabolism, signal transduction, cell cycle and oxidative stress response. Further, deregulation of several genes associated with carcinogenesis or tumor progression including Ccnd1, Egfr, Map2k3, Mcm2, Orc2l and Smad2 was observed. Although transcription changes in identified genes are unlikely to be used as a sole indicator of adverse health effects, the results of this study could enhance our understanding of early toxic effects of drinking water exposure and support future studies on drinking water safety. Copyright © 2009 John Wiley & Sons, Ltd.

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