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Gene expression pattern of signal transduction in chronic myeloid leukemia

✍ Scribed by Li Huiyu; Jie Shenghua; Guo Tiannan; Huang Shi'ang


Publisher
Wuhan University
Year
2006
Tongue
English
Weight
940 KB
Volume
11
Category
Article
ISSN
1007-1202

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Unusual expression of mRNA typical of Ph
✍ Kirk, Judy A.; Radich, Jerald; Edmands, Scott; Lee, Arthur; VanDevanter, Donald πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 647 KB

The Philadelphia chromosome (Ph) is found in both chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). The Ph translocation, t(9;22)(q34;qll), can disrupt the BCR gene on chromosome 22 in one to two areas called the major (Mbcrl) and minor (mbcrl) breakpoint cluster regions. In CML