Gene expression of the transporters and biosynthetic enzymes of the osmolytes in astrocyte primary cultures exposed to hyperosmotic conditions

The putative heme transporter HCP1 is ex

The putative heme transporter HCP1 is expressed in cultured astrocytes and contributes to the uptake of hemin

✍ Theresa N. Dang; Glenda M. Bishop; Ralf Dringen; Stephen R. Robinson 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 381 KB

## Abstract Hemin, which is toxic to brain cells, has been reported to be taken up by cultured astrocytes; however, the mechanism of uptake is currently unknown. The present study investigated the mechanism of hemin uptake by rat primary astrocyte cultures. In medium containing 10% fetal calf serum