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Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines

✍ Scribed by Arabelle Pfrunder; Heike Gutmann; Christoph Beglinger; Jürgen Drewe


Book ID
118111334
Publisher
Pharmaceutical Press
Year
2003
Tongue
English
Weight
334 KB
Volume
55
Category
Article
ISSN
2042-7158

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CYP3A4, CYP3A5, and MDR1 in human small
✍ Helena A. Engman; Hans Lennernäs; Jan Taipalensuu; Charlotta Otter; Brith Leidvi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 251 KB

The aim of this study was to ®nd a cell culture model of the intestinal epithelium for use in studies of CYP3A4-mediated ®rst-pass metabolism of drugs and also for studies of the interplay between CYP3A4 metabolism and P-glycoprotein ef¯ux. For this purpose, the expression of CYP3A4, CYP3A5, and MDR