Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma
β Scribed by Nakayama, Robert; Nemoto, Takeshi; Takahashi, Hiro; Ohta, Tsutomu; Kawai, Akira; Seki, Kunihiko; Yoshida, Teruhiko; Toyama, Yoshiaki; Ichikawa, Hitoshi; Hasegawa, Tadashi
- Book ID
- 109889588
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 651 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0893-3952
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## Abstract ## BACKGROUND Prognostic factors for metastasis in soft tissue sarcoma govern decisions regarding adjuvant treatment. However, the significance of initial tumorβrelated prognostic factors over time is largely unknown. ## METHODS The current study included 338 patients with malignant
Background. p53 mutations are the most frequently observed tumor-related genetic changes. Mutational analysis concerns mostly carcinomas and is not comprehensive for soft tissue sarcomas. Among soft tissue sarcomas, malignant fibrous histiocytoma (MFH) and liposarcoma represent the most frequent tum