Gene Expression Alterations in Prostate Cancer Predicting Tumor Aggression and Preceding Development of Malignancy
β Scribed by Yu, Y. P.
- Book ID
- 124150842
- Publisher
- American Society of Clinical Oncology
- Year
- 2004
- Tongue
- English
- Weight
- 499 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0732-183X
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## Abstract Recent studies have demonstrated that two SIBLING family members, bone sialoprotein (BSP) and osteopontin (OPN), are overexpressed in human prostate cancer. The expression of these proteins is associated with the acquisition of a metastatic phenotype by cancer cells and a poor prognosis
The second most common target of prostate-cancer metastasis is bone, and the phenomenon of skeletal metastasis represents the incurable stage of disease. Histologically, skeletal metastasis from prostate cancer is distinctive due to its osteoblastic nature. The osteoblastic bone metastasis shows ext