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Gene-environment interactions in the pre–Industrial Era: the cancer of King Ferrante I of Aragon (1431-1494)

✍ Scribed by Laura Ottini; Mario Falchetti; Silvia Marinozzi; Luciana Rita Angeletti; Gino Fornaciari

Book ID
116534887
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
980 KB
Volume
42
Category
Article
ISSN
1532-8392

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K-ras mutation in the tumour of King Fer
K-ras mutation in the tumour of King Ferrante I of Aragon (1431–1494) and environmental mutagens at the Aragonese court of Naples
✍ Gino Fornaciari; Antonio Marchetti; Silvia Pellegrini; Rosalba Ciranni 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 404 KB

The autopsy of the mummy of Ferrante I of Aragon, King of Naples (1431 -1494) revealed an adenocarcinoma extensively infiltrating the muscles of the small pelvis. A molecular study of neoplastic tissue observed a typical mutation of the K-ras gene codon 12: the normal sequence GGT (glycine) was alte