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Gene dosage influences the age at onset of SCA2 in a family from southern Italy

✍ Scribed by P Spadafora; G Annesi; M Liguori; P Tarantino; N Cutuli; S Carrideo; IC Cirò Candiano; EV De Marco; D Civitelli; F Annesi; S Giuffrida; A Quattrone

Book ID
110888463
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
115 KB
Volume
72
Category
Article
ISSN
0009-9163

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## Abstract We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (N = 437 families). Families were subset as late‐onset (320 families, AAO ≥65) and early/mixed (117 families, at least 1 member with 50< AAO <65). Treating AAO as a censored trait, we