Gene dosage effect in human triploid fibroblasts

✍ Scribed by C. Junien; H. Rubinson; J. C. Dreyfus; M. C. Meienhofer; N. Ravise; J. Boué; A. Boué

• Book ID: 104778185
• Publisher: Springer
• Year: 1976
• Tongue: English
• Weight: 299 KB
• Volume: 33
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00447287

✦ Synopsis

The activity of 13 cytoplasmic enzymes has been determined in fibroblast extracts from 9 triploid and 13 control lines. The results show a high activity for 2 X-linked enzymes, glucose 6-phosphate dehydrogenase and phosphoglycerate kinase. These data, together with cytogenetic observations, support the contention that 2 X chromosomes were active in the triploid lines.