Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase

Towards gene therapy in prosthesis loose

Towards gene therapy in prosthesis loosening: efficient killing of interface cells by gene-directed enzyme prodrug therapy with nitroreductase and the prodrug CB1954

✍ Jolanda J. de Poorter; Tanja C. A. Tolboom; Martijn J. W. E. Rabelink; Elsbet Pi 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 157 KB

## Background: Loosening is a major complication in prosthesis surgery. to stabilize loosened orthopedic implants, the interface tissue surrounding the implant must be removed. as an alternative to manual removal, we explored the possibility of removing the tissue by gene-directed enzyme prodrug th