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Gene directed enzyme prodrug therapy for cancer

✍ Scribed by I.A McNeish; P.F Searle; L.S Young; D.J Kerr

Book ID
114176443
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
480 KB
Volume
26
Category
Article
ISSN
0169-409X

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## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar