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Gene Delivery to the Epidermal Cells of Human Skin Explants Using Microfabricated Microneedles and Hydrogel Formulations

✍ Scribed by Marc Pearton; Chris Allender; Keith Brain; Alexander Anstey; Chris Gateley; Nicolle Wilke; Anthony Morrissey; James Birchall


Book ID
106493210
Publisher
Springer US
Year
2007
Tongue
English
Weight
405 KB
Volume
25
Category
Article
ISSN
0724-8741

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## Abstract ## Background Current liposome‐based gene delivery methods for therapeutic benefit are limited by their low efficiency. One possible way to improve gene expression is to include a peptide with a nuclear localization signal (NLS) to enhance the movement of the transfection complex from