𝔖 Bobbio Scriptorium
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Gene-based approaches toward Friedreich ataxia therapeutics

✍ Scribed by M. D. Hebert; A. A. Whittom


Book ID
105758698
Publisher
Springer
Year
2007
Tongue
English
Weight
497 KB
Volume
64
Category
Article
ISSN
1420-682X

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TALEs targeting a promoter sequence and fused with a transcription activation domain (TAD) may be used to specifically induce the expression of a gene as a potential treatment for haploinsufficiency. This potential therapeutic approach was applied to increase the expression of frataxin in fibroblast