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Gene amplifications in advanced-stage human prostate cancer

✍ Scribed by Fournier, G. ;Latil, A. ;Amet, Y. ;Abalain, J. H. ;Volant, A. ;Mangin, P. ;Floch, H. H. ;Lidereau, R.

Publisher: Springer
Year: 1995
Tongue: English
Weight: 570 KB
Volume: 22
Category: Article
ISSN: 0300-5623
DOI: 10.1007/bf00296872

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✦ Synopsis

Gene amplification is a model of proto-oncogene alterations occasionally observed in human tumors. This amplification can, in some cases, have prognostic value (N-myc in neuroblastoma, c-erbB2 and int-2 in breast cancer, etc.). Amplifications of the proto-oncogenes c-myc, c-erbB2 and int-2 have not yet been report in prostate adenocarcinoma, which, like breast cancer, is hormone dependent. We sought amplifications of these three proto-oncogenes by means of Southern blotting in 15 human prostate adenocarcinoma specimens, most of which were advanced (7 stage C and 6 stage D1 or D2). We confirmed the lack of c-myc and c-erbB2 amplification, regardless of the stage, in contrast to the case of breast cancer. Int-2 amplification was observed in one advanced tumor with bone metastases, out of a total of six stage D tumors. The precise frequency of int-2 amplification and its role in prostate carcinogenesis remain to be determined.

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