Gene amplification in thyroid cancer: A new mechanism defined by CGH and A BAC map of the human genome

Multiple mechanisms of action of ZR2002

Multiple mechanisms of action of ZR2002 in human breast cancer cells: A novel combi-molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA

✍ Fouad Brahimi; Zakaria Rachid; Qiyu Qiu; James P. McNamee; Yu-Jiang Li; Ana M. T 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 276 KB 👁 2 views

## Abstract The mechanism of action of ZR2002, a chimeric amino quinazoline designed to possess mixed EGFR tyrosine kinase (TK) inhibitory and DNA targeting properties, was compared to those of ZR01, a reversible inhibitor of the same class and PD168393, a known irreversible inhibitor of EGFR. ZR20