𝔖 Bobbio Scriptorium
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Gender, immunity and the regulation of longevity

✍ Scribed by Robin C. May

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
167 KB
Volume
29
Category
Article
ISSN
0265-9247

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✦ Synopsis

Abstract

For humans and many other animals, gender is a fact of life. Most individuals are born either male or female and their sex will have an enormous influence on their behaviour, physiology and life history. In this review, I consider the effect gender has on lifespan. In particular, I discuss the role played by behaviour, immunity and oxidative damage in determining sex‐dependent differences in longevity. I consider existing explanations for the effect of gender on lifespan and how these explanations fit together. Finally, I expand on the recent suggestion of a key role for the insulin/IGF‐1 signalling pathway in regulating sex‐dependent differences in lifespan(1) and I highlight a number of areas for future investigation. BioEssays 29:795–802, 2007. Β© 2007 Wiley Periodicals, Inc.

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