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Gender- and morphine dose-linked expression of spontaneous somatic opiate withdrawal in mice

✍ Scribed by Francesco Papaleo; Angelo Contarino

Book ID
116284208
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
365 KB
Volume
170
Category
Article
ISSN
0166-4328

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Methylxanthines produce a quasi-morphine withdrawal syndrome (QMWS) in opiate naive rats. Additionally, methylxanthine-induced suppression of conditioned behavior in rats is reversed by the alpha2 adrenergic agonist clonidine which also attenuates true opiate withdrawal and the QMWS. Therefore, the