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Gemtuzumab ozogamicin (Mylotarg) has therapeutic activity against CD33+ acute lymphoblastic leukaemias in vitro and in vivo

✍ Scribed by J. Golay; N. Di Gaetano; D. Amico; E. Cittera; A. M. Barbui; R. Giavazzi; A. Biondi; A. Rambaldi; M. Introna


Book ID
108672989
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
257 KB
Volume
128
Category
Article
ISSN
0007-1048

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## Abstract CD19 is an attractive therapeutic target for treating human B‐cell tumors. In our study, chimeric (c) divalent (cHD37) and tetravalent (cHD37‐DcVV) anti‐CD19 monoclonal antibodies (MAbs) were constructed, expressed and evaluated for their binding to human 19‐positive (CD19^+^) tumor cel