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Gelsemine: A Thought-Provoking Target for Total Synthesis

✍ Scribed by Hong Lin; Samuel J. Danishefsky

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 779 KB
Volume: 42
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200390048

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✦ Synopsis

Abstract

Gelsemine and 21‐oxogelsemine have been synthesized through several routes. This Review focuses on the comparison of the different strategies to assemble the bicyclo[3.2.1]octane core, to introduce the bridgehead quaternary C20 to form the pyrrolidine moiety, to construct the oxindole residue, and to close the tetrahydropyran ring en route to gelsemine.

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