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Geldanamycin-induced degradation of Chk1 is mediated by proteasome

✍ Scribed by M. Nomura; N. Nomura; J. Yamashita


Book ID
116291088
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
174 KB
Volume
335
Category
Article
ISSN
0006-291X

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## Abstract As an oncoprotein, mutant p53 is a potential tumor‐specific target for cancer therapy. Most mutated forms of the protein are largely accumulated in cancer cells due to their increased stability. In the present study, we demonstrate that mutant p53 protein stability is regulated by gambo