Gelatin/PLLA Sponge-Like Scaffolds Allow Proliferation and Osteogenic Differentiation of Human Mesenchymal Stromal Cells
✍ Scribed by Letizia Mattii; Barbara Battolla; Delfo D'Alessandro; Luisa Trombi; Simone Pacini; Maria Grazia Cascone; Luigi Lazzeri; Nunzia Bernardini; Amelio Dolfi; Sara Galimberti; Mario Petrini
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 708 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
Tissue engineering has the potential to supply constructs capable of restoring the normal function of native tissue following injury. Poly(L‐lactic acid) (PLLA) scaffolds are amongst the most commonly used biodegradable polymers in tissue engineering and previous studies performed on ovine fibroblasts have showed that addition of gelatin creates a favorable hydrophilic microenvironment for the growth of these cells. The attractiveness of using mesenchymal stromal cells (MSCs) in tissue regeneration is that they are able to differentiate into several lines including osteoblasts. In this study, we investigated the ability of gelatin/PLLA sponges to support the adhesion, proliferation, and osteogenic differentiation of human MSCs isolated from the bone marrow of four donors.
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