Gelatinase A (MMP-2), Collagenase-2 (MMP-8), and Laminin-5 γ2-Chain Expression in Murine Inflammatory Bowel Disease (Ulcerative Colitis)

β-Catenin activates a coordinated expres

β-Catenin activates a coordinated expression of the proinvasive factors laminin-5 γ2 chain and MT1-MMP in colorectal carcinomas

✍ Falk Hlubek; Simone Spaderna; Andreas Jung; Thomas Kirchner; Thomas Brabletz 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 309 KB

## Abstract In colorectal carcinomas, loss‐of‐function mutations of the adenomatous polyposis coli (APC) tumor suppressor gene lead to a nuclear accumulation of the oncogenic transcriptional activator β‐catenin, predominantly at the invasive front within the tumor host interface. Various identified