Gelatin as a delivery vehicle for the controlled release of bioactive molecules
β Scribed by Simon Young; Mark Wong; Yasuhiko Tabata; Antonios G. Mikos
- Book ID
- 113691069
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 208 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0168-3659
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This work evaluated gelatin microparticles and biodegradable composite scaffolds for the controlled release of bone morphogenetic protein-2 (BMP-2) in vitro and in vivo. Gelatin crosslinking (10 and 40 mM glutaraldehyde), BMP-2 dose (6 and 60 ng BMP-2 per mg dry microparticles), buffer type (phospha
## Abstract Uniform gelatin microspheres (GMS) of a wet size of 100 Β΅m in diameter were fabricated by the electric field assisted precision particle fabrication (EβPPF) method and crosslinked with different glutaraldehyde (GA) concentrations to study the effect of the crosslinking density on drug r