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Gefitinib (‘IRESSA’, ZD1839) inhibits EGF-induced invasion in prostate cancer cells by suppressing PI3

✍ Scribed by Lorella Bonaccorsi; Sara Marchiani; Monica Muratori; Gianni Forti; Elisabetta Baldi

Book ID: 106123379
Publisher: Springer-Verlag
Year: 2004
Tongue: English
Weight: 631 KB
Volume: 130
Category: Article
ISSN: 1432-1335
DOI: 10.1007/s00432-004-0581-8

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## Abstract The epidermal growth factor (EGF) plays a role in the development of prostate cancer, which becomes essential after androgen resistance has emerged. The EGF receptor (EGFR) is therefore a potential target for anticancer therapy. We evaluated the effects of ZD1839 (‘Iressa’), an orally a