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Gefitinib inhibits the cross-talk between mesenchymal stem cells and prostate cancer cells leading to tumor cell proliferation and inhibition of docetaxel activity

✍ Scribed by Borghese, Cinzia; Cattaruzza, Lara; Pivetta, Eliana; Normanno, Nicola; De Luca, Antonella; Mazzucato, Mario; Celegato, Marta; Colombatti, Alfonso; Aldinucci, Donatella

Book ID
120218612
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
995 KB
Volume
114
Category
Article
ISSN
0730-2312

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## Abstract 3,3′‐Diindolylmethane (DIM) has been studied for its putative anti‐cancer properties, especially against prostate cancer; however, its exact mechanism of action remains unclear. We recently provided preliminary data suggesting down‐regulation of uPA during B‐DIM (a clinically active DIM