GDNF and NT-4 Protect Midbrain Dopaminergic Neurons from Toxic Damage by Iron and Nitric Oxide

C-Jun N-terminal kinase inhibition and α

C-Jun N-terminal kinase inhibition and α-tocopherol protect midbrain dopaminergic neurons from interferon-γ/lipopolysaccharide-induced injury without affecting nitric oxide production

✍ Haruki Shibata; Hiroshi Katsuki; Mitsugi Okawara; Toshiaki Kume; Akinori Akaike 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 352 KB

Interferon-gamma (IFN-gamma)/lipopolysaccharide (LPS) induces delayed dopaminergic neuron loss in midbrain slice cultures, because of nitric oxide production resulting from p38 mitogen-activated protein kinase (p38 MAPK)-dependent induction of inducible nitric oxide synthase (iNOS). In this study, w