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GdDTPA-enhanced magnetic resonance imaging of the aqueous flow in the rabbit eye

✍ Scribed by Hong-Ming Cheng; Kenneth K. Kwong; Jing Xiong; Chen Chang

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
358 KB
Volume
17
Category
Article
ISSN
0740-3194

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✦ Synopsis

Magnetic resonance imaging with gadolinium-diethylenetriaminepentaacetic acid complex (GdDTPA) as the contrast agent was used to image the aqueous chamber of the eye. This method, in addition to providing spatial information, permits quantitative study of the aqueous flow. GdDTPA solution was applied either topically or intravenously, entering the anterior chamber via different pathways. The wash-in and wash-out of GdDTPA follow a two-compartment model which enables determination of the aqueous flow rate by multiplying the aqueous chamber volume by the wash-out rate constant. Rabbit eyes showed a flow rate of 1.5-2 microliters/min which was retarded by the systemic administration of acetazolamide (Diamox).

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