Serum concentrations of the actin scavenger Gc-globulin may provide prognostic information in acute liver failure (ALF). The fraction of Gc-globulin not bound to actin is postulated to represent a better marker than total Gc-globulin but has been difficult to measure. We tested a new rapid assay for
Gc-globulin to predict outcome in acute liver failure: A panacea?
β Scribed by Rajiv Jalan
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 53 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1527-6465
- DOI
- 10.1002/lt.20507
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Serum concentrations of the actin scavenger Gc-globulin are reduced in acute liver failure (ALF). Prospectively, we tested Gc-globulin's value to predict outcome following ALF using sera from 182 patients with ALF from the U.S. ALF Study Group. Admission serum levels of Gc-globulin (normal range: 35
Reductions in serum levels of Gc globulin, a hepatically synthesized component of the extracellular actin scavenger system responsible for complexing circulating actin and attenuating intravascular microthrombus formation, are associated with poor outcome in acute liver failure. Clinically applicabl
Acute liver failure (ALF) in children is an uncommon but devastating medical condition. Specific therapy is not available except for a handful of etiologies, such as ALF due to hereditary tyrosinemia or acetaminophen (APAP) overdose.
Little information is available on acute liver failure (ALF) in the United States. We gathered demographic data retrospectively for a 2-year period from July 1994 to June 1996 on all cases of ALF from 13 hospitals (12 liver transplant centers). Data on the patients included age, hepatic coma grade o