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Gas-liquid chromatographic determination of mefenamic acid in human serum

✍ Scribed by L.J. Dusci; L.P. Hackett

Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
176 KB
Volume
161
Category
Article
ISSN
1873-3778

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✦ Synopsis

Mefenamic acid (Ponstan) is used as an analgesic and anti-inflammatory agent in the management of rheumatoid arthritis 1---i. Several analytical methods have been published for its analysis including thin-layer chromatography', fluorimetry6e7, colorimetryS and electroncapture gas-liquid chromatography9.

The -method described in this paper was devised for the estimation of the drug at therapeutic levels and in cases of overdosage. The procedure is rapid, the acid being butylated with iodobutane, and allows the drug concentrations to be analysed down to a level of 1 mg/l using 2 ml of serum.

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