Gas-flow assisted ion transfer for mass spectrometry
β Scribed by Sandilya Garimella; Wei Xu; Guangming Huang; Jason D. Harper; R Graham Cooks; Zheng Ouyang
- Book ID
- 102383049
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 407 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1076-5174
- DOI
- 10.1002/jms.2955
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β¦ Synopsis
Methods and devices that use gas flows to collect ions and transfer them over long distances for mass spectrometric analysis have been developed. Gas flows derived from the ionization source itself or provided by means of additional pumping were used to generate a laminar flow inside cylindrical tube. Hydrodynamic simulations and experimental tests demonstrate that laminar flow can transfer ions over long distance. The typical angular discrimination effects encountered when sampling ions from ambient ionization sources are minimized, and the sampling of relatively large surface areas is demonstrated with desorption electrospray ionization (DESI). Ion transfer over 6βm has been achieved and its application to multiplexed chemical analysis is demonstrated on samples at locations remote from the mass spectrometer. Copyright Β© 2012 John Wiley & Sons, Ltd.
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