Gas chromatography of trimethylsilylated bases and nucleosides
β Scribed by Yukiko Sasaki; Takeshi Hashzume
- Publisher
- Elsevier Science
- Year
- 1966
- Tongue
- English
- Weight
- 1022 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0003-2697
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## Abstract The separation of 12 model compounds chosen among purine and pyrimidine bases and nucleosides was studied by using hydrophilic interaction chromatography (HILIC). The compounds investigated were small molecules with relevant properties for biomedical and pharmaceutical studies. The mixt
After silylation,\* some nonvolatile biological compounds are converted to volatile derivatives that can be analyzed by gas chromatographic separation techniques. Notable success has been achieved with carbohydrates, in which silylation proceeds quickly with a mixture of hexamethyldisilazane and tri