Gas chromatographic measurement of levels of fenfluramine and norfenfluramine in human plasma red cells and urine following therapeutic doses

✍ Scribed by D.B. Campbell

• Publisher: Elsevier Science
• Year: 1970
• Tongue: English
• Weight: 470 KB
• Volume: 49
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)93657-4

✦ Synopsis

A specific and sensitive procedure for the determination of fenfluramine and norfenfluramine at therapeutic levels in human plasma, red cells and urine has been developed. The method involves extraction of the drugs from alkalinised samples into diethyl ether or dichloroethane, with subsequent separation and detection on a gasliquid chromatograph fitted with a flame ionisation detector. N,N-Diethylaniline is used as an internal standard for quantitation by the relative peak area technique. Levels encountered after oral ingestion of a single therapeutic dose are reported.