✦ LIBER ✦

Gas chromatographic identification and quantification of hydroxyzine: Application in a fatal self-poisoning

✍ Scribed by P Kintz; B Godelar; P Mangin

Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 319 KB
Volume: 48
Category: Article
ISSN: 0379-0738
DOI: 10.1016/0379-0738(90)90106-9

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✦ Synopsis

A method for the identification and quantification of hydroxyzine in human fluids by GUNPD is presented. The method employs acepromazine as the internal standard and requires no derivatization. After a single alkaline extraction in n-heptane isoamylalcohol (g&5:1.5, v/v), analysis is achieved in 7 min. The lower limit of detectability was 0.8 ng/ml in plasma. Capillary gas chromatography mass spectrometry assay was developed for confirmation. Toxicological findings, after a fatality involving hydroxyzine are presented as an application of the procedure.

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