The absorption, distribution, and metabolic fate of N-7-phenylpropyl-N-benzyloxy acetamide (W-1372) was studied in the rat, dog, and monkey. W-1372-14C was readily absorbed by all three species. Following an oral dose, peak blood levels of radioactivity were attained within 1 hr. in the monkey and i
Gas chromatographic determination of N-γ-phenylpropyl-N-benzyloxy acetamide (W-1372) in blood
✍ Scribed by J. F. Douglas; J. A. Stockage
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 172 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
A procedure is described for the determination of N-7-phenylpropyl-N-benzyloxy acetamide (W-1372) in plasma or whole blood. W-1372 is extracted from plasma with hexane and measured quantitatively by gas chromatography. The technique is simple, reproducible, and accurate in the range of 1-10 mcg./ml. Dibutyl phthalate is used as the internal standard for quantitation by the relative peak area method.
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