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Gap junctions and ACTH sensitivity in Y-1 adrenal tumor cells

✍ Scribed by Decker, R. S. ;Donta, S. T. ;Larsen, W. J. ;Murray, S. A.

Publisher
Wiley (John Wiley & Sons)
Year
1978
Tongue
English
Weight
1004 KB
Volume
9
Category
Article
ISSN
0091-7419

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✦ Synopsis

Initial studies of adrenocorticotropin-sensitive (ACTH-sensitive) and ACTHinsensitive Y-1 adrenal cortical tumor cell lines suggest a relationship between responsiveness to ACTH and the presence of gap junctions. An ACTH-sensitive clone of Y-1 cells possesses gap junctions and these junctions appear to enlarge with ACTH treatment. Gap junctions have not been observed, however, in an ACTH-insensitive clone of Y-1 tumor cells even when stimulated to produce cyclic adenosine monophosphate and steroids with cholera toxin.

Key words: adrenal cortical tumor cells

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