## Abstract The neural cell adhesion molecule (NCAM) is one of the bestβcharacterized cell adhesion molecules of the immunoglobulin superfamily. In the nervous system, NCAM is involved in cell migration, axon fasciculation and in neurite outgrowth. Neurite outgrowth is mediated by homophilic NCAMβN
GAP-43 regulates NCAM-180-mediated neurite outgrowth
β Scribed by Irina Korshunova; Vera Novitskaya; Darya Kiryushko; Nina Pedersen; Kateryna Kolkova; Ekaterina Kropotova; Mark Mosevitsky; Mikhail Rayko; John S. Morrow; Irith Ginzburg; Vladimir Berezin; Elisabeth Bock
- Book ID
- 111179935
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 831 KB
- Volume
- 0
- Category
- Article
- ISSN
- 0022-3042
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## Interactions between the neural cell adhesion molecule (NCAM ) with NCAM-expressing neurons (transinteraction) stimulate outgrowth of neurites. The extent of NCAM-triggered neurite outgrowth depends on the presence of 10 amino acids derived from the variable alternatively spliced exon (VASE or
Robust process outgrowth and high expression of the growth-associated protein GAP-43 seem to be intrinsic features of neurons, but both are down-regulated after axonal contact of target cells. We report that chronic exposure of the serotonergic CNS cell line RN46A to cyclic AMP analogs, forskolin, o