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Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells

โœ Scribed by Ue-Min Chang; Chyi-Hann Li; Liang-In Lin; Cheng-Po Huang; Lou-Sing Kan; Shwu-Bin Lin


Book ID
116718659
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
513 KB
Volume
79
Category
Article
ISSN
0024-3205

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Hepatocyte growth factor (HGF) exerts a cytostatic effect on HepG2 and B16-F1 cell lines. To evaluate the possible involvement of the apoptotic process in this effect, we performed studies at cellular and molecular levels. HGF induced apoptosis only in HepG2 hepatoma cells at day 3 in about 20% of t