Gangliosides of Human Melanoma
β Scribed by Tsuchida, Tetsuya ;Irie, Reiko F. ;Ishibashi, Yasumsa
- Book ID
- 111259440
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 236 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0893-5785
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The inability of current therapy to prevent metastases arising from uveal melanoma often results in patient mortality. With the goal of developing a treatment for metastasis, gangliosides were studied as potential tumor-associated antigens. Our report describes the production of a metastatic liver v
## Abstract We have evaluated the ganglioside composition of 20 primary uveal melanomas, of 2 cell lines derived from 2 uveal melanomas, of a liver metastasis from an uveal melanoma, and 8 of normal choroids. The results show that normal choroid tissue has a ganglioside content similar to the prima
Gangliosides appear to be important target molecules for immunological effector mechanisms on neuro-ectodermal tumors. Therefore in vitro studies were performed to examine whether ganglioside GD3, which is highly expressed on the cell surface of cultured human melanoma cells, is being shed into the