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Gangliosides fail to enhance behavioral recovery after bilateral ablation of the visual cortex

✍ Scribed by W. M. Butler; E. Griesbach; R. Labbe; D. G. Stein

Book ID
102911861
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
691 KB
Volume
17
Category
Article
ISSN
0360-4012

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✦ Synopsis

Postsurgical injections of GM1 gangliosides (30 mg/kg IP) reduced neither behavioral deficits in rats following bilateral ablation of the visual cortex nor the extent of retrograde degeneration of neurons in the dorsolateral geniculate nucleus that typically accompanies large lesions of the visual cortex. Our findings are in contrast to previous research, in which ganglioside treatments have been shown to enhance the rate of functional recovery after lesions in other parts of the central nervous system. The negative findings in the present experiment may be due to the disruption of normal circadian rhythms caused by occipital cortex injury.

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✍ Larsson, Knut πŸ“‚ Article πŸ“… 1964 πŸ› John Wiley and Sons 🌐 English βš– 652 KB

In an earlier paper (Larsson, '62) it was reported that bilateral lesions in the lateral parieto-temporal area of the cerebral hemispheres have more severe effects upon the mating behavior of male rats than injury to the medial parts of the frontal, parietal, and occipital lobes. Whereas lateral les