Gangliosides and Neuronal Plasticity

✍ Scribed by H. Egge, J. Peter-Katalinić (auth.), Guido Tettamanti, Robert W. Ledeen, Konrad Sandhoff, Yoshitaka Nagai, Gino Toffano (eds.)

• Publisher: Springer-Verlag New York
• Year: 1986
• Tongue: English
• Leaves: 477
• Series: FIDIA Research Series 6
• Edition: 1
• Category: Library

✦ Synopsis

This volume contains the Proceedings of the Meeting "Neuronal plasticity and gangliosides" which was held at Mantova, Italy, on May 29-31, 1985, as a satellite to the Tenth Meeting of the International Society for Neurochemistry, (Riva del Garda, Italy, May 19-24,1985). The Symposium took place in the "Teatro Bibiena", one of the oldest and most beautiful theatres in Italy, known for having been the place for some of the very first performances of W .A. Mozart. The number of registered participants in the Meeting was about 180 including 40 accor:Qpanying persons. The persons invited as Speakers or Chairmen of Colloquia and Workshops were 48. Eighteen countries were represented with the largest contingent coming from Italy, followed by Federal Republic of Germany, The United States, France and Great Britain. The Meeting was based on Colloquia, Workshops, Round Tables and Poster Sessions, with a total of 42 Lectures and 32 Poster presentations.

✦ Table of Contents

Front Matter....Pages I-XIII
A Review of Mass Spectrometric Techniques in the Structural Analysis of Native and Derivatized Gangliosides....Pages 1-15
Advances in Ganglioside Chemistry....Pages 17-46
The Solution Conformation of Gangliosides Inferred from HSEA Calculations and High Field NMR Spectroscopy....Pages 47-56
A Novel Disialoganglioside (GD1 α ) with N-Acetylneuraminyl ( α 2 → 6)-N-Acetylgalactosamine Linkage in Rat Ascites Hepatoma Cells....Pages 57-66
Topographical Distribution of the Gangliosides in the Developing and Adult Human Brain....Pages 67-76
The Use of Antibodies to Identify Glycosphingolipids and to Localize Them in Tissues....Pages 77-82
Expression of Ganglioside-Antigens During Neuronal Differentiation Studied by Use of Monoclonal Antibodies....Pages 83-93
Gangliosides as Differential Modulators of Membrane-Bound Protein Kinase Systems....Pages 95-104
Membrane Aging of the Brain Synaptosomes with Special Reference to Gangliosides....Pages 105-112
Possible Association of Degenerative Motor Neuron Disease (ALS) with Abnormal Ganglioside Metabolism: Abnormal Gangliosides in ALS Spinal Cord and ALS-Like Symptoms in a Unique Partial HexB Deficiency Syndrome....Pages 113-124
Ultrastructural Localization of Calcium at Synapses and Modulatory Interactions with Gangliosides....Pages 125-135
Involvement of Gangliosides in the Synaptic Transmission in the Hippocampus and Striatum of the Rat Brain....Pages 137-151
Antibody to Glycolipid in a Patient with IgM Paraproteinemia and Polyradiculoneuropathy....Pages 153-159
Axonal Transport of Gangliosides and Neutral Glycolipids in the Peripheral Nervous System. Identification of Ganglioside Types in Motoneurons of the PNS....Pages 161-169
Concepts of Ganglioside Metabolism....Pages 171-182
Metabolism of Exogenous GM1 and Related Glycolipids in the Rat....Pages 183-200
Ganglioside-Mediated Modulation of Growth Factor Receptor Function....Pages 201-214
Neuritic Responses to GM1 Ganglioside in Several in Vitro Systems....Pages 215-230
Functional Analysis of Ganglioside-Respondable Human Neuroblastoma Cell Lines....Pages 231-244
Primary Neural Cell Cultures and GM1 Monosialoganglioside: A Model for Comprehension of the Mechanisms Underlying GM1 Effects in CNS Repair Process in Vivo....Pages 245-255
Modulation of Neurite Outgrowth and Ganglioside Associated Changes in Cerebral Neurons and PC12 Pheochromocytoma Cells....Pages 257-269
Ganglioside Effects on Astroglial Cells in Vitro....Pages 271-282
The Role of Gangliosides in Neurotrophic Interaction in Vitro....Pages 283-293
Evidence for the Effects of Gangliosides on the Development of Neurons in Primary Cultures....Pages 295-307
Facilitated-Establishment of Contacts and Synapses in Neuronal Cultures: Ganglioside-Mediated Neurite Sprouting and Outgrowth....Pages 309-325
Effect of Added Gangliosides on the Development of Fetal Mouse Spinal Cord-Dorsal Root Ganglion Explants Cultured in a Chemically Defined Medium....Pages 327-333
Molecular Specificity of Ganglioside Action on Neurite Regeneration in Cell Cultures of Sensory Neurons....Pages 335-346
New Evidence for the Morphofunctional Recovery of Striatal Function by Ganglioside GM1 Treatment Following a Partial Hemitransection of Rats. Studies on Dopamine Neurons and Protein Phosphorylation....Pages 347-364
Behavioral and Neurochemical Alterations Induced by Exogenous Gangliosides in Brain Damaged Animals: Problems and Perspectives....Pages 365-380
Studies on the Involvement of Polyamines for the Trophic Actions of the Ganglioside GM1 in Mechanically and 6-hydroxydopamine Lesioned Rats. Evidence for a Permissive Role of Putrescine....Pages 381-396
The Effect of GM1 on Cerebral Metabolism, Microcirculation and Histology in Focal Ischemia....Pages 397-405
Acute Effects of Gangliosides on CNS Injury....Pages 407-414
Effect of GM1 on the Alterations Induced by Selective Neurotoxins in the Developing CNS....Pages 415-425
Early Biochemical Effects of GM1 Ganglioside Treatment in Lesioned Brain: Dependence on Degree of Fiber Degeneration....Pages 427-434
Effect of GMI Ganglioside and of Its Inner Ester Derivative in a Model of Transient Cerebral Ischemia in the Rat....Pages 435-443
Early Recovery of Striatal Dopamine Uptake in Rats with Unilateral Nigro-Striatal Lesion Following Treatment with Monosialoganglioside....Pages 445-451
Motorneuron Sprouting and Spinal Plasticity in Amyotrophic Lateral Sclerosis: The “Window of Opportunity” for a Ganglioside Treatment....Pages 453-460
Subacute Phase of Stroke Treated with Ganglioside GM1....Pages 461-463
Ganglioside Therapy of Peripheral Neuropathies: A Review of Clinical Literature....Pages 465-479
Back Matter....Pages 481-485

✦ Subjects

Neurosciences; Cell Biology; Biochemistry, general