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Ganglioside-exposed dendritic cells inhibit T-cell effector function by promoting regulatory cell activity

✍ Scribed by Alessandra Jales; Rustom Falahati; Elisabeth Mari; Erik J. Stemmy; Weiping Shen; Cathy Southammakosane; Dallen Herzog; Stephan Ladisch; David Leitenberg


Book ID
108782816
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
399 KB
Volume
132
Category
Article
ISSN
0019-2805

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## Abstract We have previously shown that human monocyte‐derived dendritic cells (DC) express indoleamine 2,3‐dioxygenase (IDO), as well as several other enzymes of the kynurenine pathway at the mRNA level upon maturation. The tolerogenic mechanisms of this pathway remain unclear. Here we show that