Ganglioside complexes as new target antigens in Guillain–Barré syndrome
✍ Scribed by Ken-ichi Kaida; Daiji Morita; Mami Kanzaki; Keiko Kamakura; Kazuo Motoyoshi; Minako Hirakawa; Susumu Kusunoki
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 143 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0364-5134
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An earlier investigation from our laboratory (Ilyas AA, Willison HJ, Quarles RH, et al. Serum antibodies to gangliosides in Guillain-Barre syndrome. Ann Neurol 1988;23:440-447) demonstrating the presence of high levels of antiganglioside antibodies in the sera of 5 of 26 patients with Guillain-Barre
## Abstract The first synthesis of ganglioside GalNAc‐GD1a, featuring efficient glycan assembly and a cyclic glucosyl ceramide as a versatile unit for ganglioside synthesis is described. Although ganglioside GalNAc‐GD1a was first found as a brain ganglioside, IgG autoantibodies to GalNAc‐GD1a were