Ganglioneuroma and adenocarcinoma associated with neurofibromatosis type 1 in the colorectal region
โ Scribed by Hiroyuki Tomita; Kichi Miya; Hidenori Tanaka; Kuniyasu Shimokawa
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 58 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0179-1958
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Multiple genetic changes occur during the evolution of normal cells into cancer cells. It has been reported that both cyclin D1 and p53 genes play major roles in oncogenesis and/or cell cycle control in various cancers. In this study, we examined the overexpression of cyclin D1 and p53 by the immuno
A large four-generation family with Noonan syndrome (NS) and neurofibromatosis-type 1 (NF1) was studied for clinical association between the two diseases and for linkage analysis with polymorphic DNA markers of the NF1 region in 17q11.2. Nonrandom segregation between NS and "1 phenotypes was observe
## Communicated by Haig H. Kazazian One of the main features of neurofibromatosis type 1 (NF1) is benign neurofibromas, 10-20% of which become transformed into malignant peripheral nerve sheath tumors (MPNSTs). The molecular basis of NF1 tumorigenesis is, however, still unclear. Ninety-one tumors
Neurofibromatosis type 2, a disease characterized by the formation of multiple nervous system tumors, especially schwannomas, is caused by mutation in the gene-encoding merlin/schwannomin. The molecular mechanism by which merlin functions as a tumor suppressor is unknown, but is hypothesized to invo